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全球最大CRISPR工具平台(蛋白/mRNA)
The World's Largest Precision Gene/Base/Prime Editing Arsenal
-80℃储存,低温运输。
产品编号 | 产品名称 | 包装 |
N1038 | NovaIscB mRNA (1mg/ml) | 100/1000μg |
基于天然IscB基因工程核酸酶,NbaCas9-1的REC结构域增强双链结合,引入swap 49/11延长有效引导至20 nt,结合点突变(E137K/E409R/I533K)提升活性,截短ωRNA(减少59 nt)增强稳定性。
蛋白结构紧凑(614 aa),适合AAV递送。TAM偏好NTAAA(兼容CTAAA/TTAAA)。
脱靶率14.3%(与SpCas9相当)。
Indel活性较野生型提升100倍(最高40%),接近SpCas9的80%。
CDS (2019nt):
atgggatctccaaaaaagaaacggaaggtgggatctagatacgtgtacgtgctggatgtggacggcaagcctctgatgcctacatgcaggttcggcaaggtgcggagaatgctgaaatctggccaagctaaggccgtggacaccctg
cctttcaccatccagctgacctacaagcccagaaccagaatcctgcaacctgtgaccctgggccaggaccccggcagaaccaatatcggaatggccgccgtgcggttcgacggcaaggaactgggaagattccactgcatcacaag
aaacaaggaaatccctaagctgatggccgacagaatggcagccagaaaggcctcccggagaggcgagagactggccagaaagcgcctggcccggaaactgcacaccaccgccaagcacctgaatggcagaatcctgccagga
tgtagcgagcccatcgccgtgaaggacatcatcaacacagagagcagattcaacaacagaatcctgaccaaatgcaaagtgtgcggcaagaacacccctctgagaagaaacgtgcgggaactcctgctggaaaacatcgtgaaga
acatcagactgcacggccctggcggagagatcgtgggcctgcaccccgacctgaaggaaacactcaagagaaccatcctggaaggccagcagggcaatatcaacaagctgttcaggaaacttagaaaggtgtacaagatcaccct
gaaccagaaagactggcctggcaaaaacctgaccgatatcgctaagaataagctgccaggccggctgcccttctgcaaggagcacttcgccgagaacgagaagttcaccaccatcgagaagagcaccttccggctgacccctacc
gccacccagctgctgcggacccacatcaacctgtttagaaagctgagcggcatcctgcccgtgaccgacgtggccgtcgagctgaacaagttcgcctttatgcagctggacaaccctgagatgaagaagcgggaaatcgacttctgc
cacggcccactgtgcggcaccggcggcctggaagccgctgttaaggagcagcaggatggaaaatgcctgctgtgtggaaaagaatctatcggccactaccaccacatcgtgcctaggtcccgtagaggcagcaacaccatcgcta
atatcgccggcctttgtcctaagtgccacgagctcgtgcacaaggacgccgatacagccgagtctctgacagagatgaaaaccggcctgatgaagaagtatggaggcaccagcgtgctgaaccagatcatccccaagctggtggaa
accctggccgacctgtttcctggccacttccacgtgacaaacggctggaacaccaaggagttcagagagaaacatcatctggaaaaggatcacgacgtggatgcttactgcatcgcctgcagccacctgaagcctgaggaaaccctg
gtggaaac………….
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