购热线:13202066085(微信同号)

订购/支持:theta_gene@163.com

公司网址:https://www.theta-gene.com

全球最大CRISPR工具平台(蛋白/mRNA

The World's Largest Precision Gene/Base/Prime Editing Arsenal

​NovaIscB mRNA

​NovaIscB mRNA

0.00
0.00
货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1038

NovaIscB mRNA (1mg/ml)

100/1000μg

 

产品简介:

基于天然IscB基因工程核酸酶,NbaCas9-1REC结构域增强双链结合,引入swap 49/11延长有效引导至20 nt,结合点突变(E137K/E409R/I533K)提升活性,截短ωRNA(减少59 nt)增强稳定性。

蛋白结构紧凑(614 aa),适合AAV递送。TAM偏好NTAAA(兼容CTAAA/TTAAA)。

脱靶率14.3%(与SpCas9相当)。

Indel活性较野生型提升100倍(最高40%),接近SpCas980%

CDS (2019nt):

atgggatctccaaaaaagaaacggaaggtgggatctagatacgtgtacgtgctggatgtggacggcaagcctctgatgcctacatgcaggttcggcaaggtgcggagaatgctgaaatctggccaagctaaggccgtggacaccctg

cctttcaccatccagctgacctacaagcccagaaccagaatcctgcaacctgtgaccctgggccaggaccccggcagaaccaatatcggaatggccgccgtgcggttcgacggcaaggaactgggaagattccactgcatcacaag

aaacaaggaaatccctaagctgatggccgacagaatggcagccagaaaggcctcccggagaggcgagagactggccagaaagcgcctggcccggaaactgcacaccaccgccaagcacctgaatggcagaatcctgccagga

tgtagcgagcccatcgccgtgaaggacatcatcaacacagagagcagattcaacaacagaatcctgaccaaatgcaaagtgtgcggcaagaacacccctctgagaagaaacgtgcgggaactcctgctggaaaacatcgtgaaga

acatcagactgcacggccctggcggagagatcgtgggcctgcaccccgacctgaaggaaacactcaagagaaccatcctggaaggccagcagggcaatatcaacaagctgttcaggaaacttagaaaggtgtacaagatcaccct

gaaccagaaagactggcctggcaaaaacctgaccgatatcgctaagaataagctgccaggccggctgcccttctgcaaggagcacttcgccgagaacgagaagttcaccaccatcgagaagagcaccttccggctgacccctacc

gccacccagctgctgcggacccacatcaacctgtttagaaagctgagcggcatcctgcccgtgaccgacgtggccgtcgagctgaacaagttcgcctttatgcagctggacaaccctgagatgaagaagcgggaaatcgacttctgc

cacggcccactgtgcggcaccggcggcctggaagccgctgttaaggagcagcaggatggaaaatgcctgctgtgtggaaaagaatctatcggccactaccaccacatcgtgcctaggtcccgtagaggcagcaacaccatcgcta

atatcgccggcctttgtcctaagtgccacgagctcgtgcacaaggacgccgatacagccgagtctctgacagagatgaaaaccggcctgatgaagaagtatggaggcaccagcgtgctgaaccagatcatccccaagctggtggaa

accctggccgacctgtttcctggccacttccacgtgacaaacggctggaacaccaaggagttcagagagaaacatcatctggaaaaggatcacgacgtggatgcttactgcatcgcctgcagccacctgaagcctgaggaaaccctg

gtggaaac………….

 

可选项: