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The World's Largest Precision Gene/Base/Prime Editing Arsenal

PpAPOBEC1-BE4 mRNA

PpAPOBEC1-BE4 mRNA

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货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1061

PpAPOBEC1-BE4   mRNA (1mg/ml)

100/1000μg

 

产品简介:

PpAPOBEC1-BE4是将PpAPOBEC1脱氨酶整合入BE4架构(nCas9(D10A)-2×UGI)的新一代CBE,可在保持高效CT编辑的同时,显著降低DNA/RNA非靶向脱氨

野生型(wt)直接替换rAPOBEC1H122AR33A点突变进一步降低脱靶(HiFi设计)

CDS (5559nt):

atgacctctgagaagggccctagcacaggcgaccccaccctgcggcggagaatcgagagctgggagttcgacgtgttctacgaccctagagaactgagaaaggaaacctgcctgctgtacgagatcaagtggggcatgagcagaa

agatctggcggagctctggcaagaacaccaccaaccacgtggaagtgaatttcatcaagaagttcaccagcgagagaaggttccacagcagcatcagctgcagcatcacctggttcctgagctggtccccttgctgggaatgcagcc

aggccatcagagagttcctgagccaacaccccggagtgacactggtgatctacgtggccagactgttctggcacatggaccagagaaacagacagggcctgagagatctggtcaacagcggcgtgactatccagatcatgcgggcc

agcgagtactaccactgttggcggaacttcgtgaactacccccccggcgatgaggcccactggcctcagtaccctcctctgtggatgatgctgtacgccctggaactgcactgcatcatcctgtctctgcctccatgtctgaagatctcta

gaagatggcagaaccacctggccttcttcagactgcacctgcagaattgccactaccagaccatccccccccacatcctgctggctacaggcctgatccacccttctgtgacctggagacttaagagcggaggatctagcggcggctct

agcggatctgagacacctggcacaagcgagtctgccacacctgagagtagcggcggatcttctggtggctctgacaagaagtacagcatcggcctggccatcggcaccaactctgtgggctgggccgtgatcaccgacgagtacaa

ggtgcccagcaagaaattcaaggtgctgggcaacaccgaccggcac………….

 

参考文献

Yu, Y. et al. Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity. Nat. Commun. 11, 2052 (2020).697(2023).

 

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