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Tad-CBE2.4 mRNA

Tad-CBE2.4 mRNA

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货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1066

Tad-CBE2.4   mRNA (1mg/ml)

100/1000μg

 

产品简介:

TadAC1.x经第二轮DNA-shuffling获得的“胞嘧啶为主”突变体TadAC2.4

TadAC1.xRYLRM基础上26个额外突变,E27KV28AP48RH51R/LI76F/YV82SL84FA106VN46LD119NH122RH123YM126IN127KS146CD147RF149YR152PQ154RE155VI156FK157NK161NT166ID167N

编辑窗口:C4-C8C编辑效率:54%±18%;残留A编辑:14%±18%。核苷酸特异性(C/A):≈15倍。

CDS (5376nt):

atgaaacggacagccgacggaagcgagttcgagtcaccaaagaagaagcggaaagtctccgaggtggaattctctcacgagtactggatgaggcatgccctgaccctggccaagcgggcctgggatgagcgggacgtgccagtg

ggcgccgtgctggtgcacaacaaccgggtcatcggcgagggctggaatagagccatcggaagacacgaccccaccgcccacgccgagatcatggccctgcggcagggcggcctggtgatgcagaactacagactgatcgacg

ccacactgtacagcacactggaaccttgtgtgatgtgcgccggcgccatgatccacagcagaatcggcagagttgtgtttggagctagatacctgagaatgggcgctgccggatctctgatgaacgtgctgcactatcctggcattaag

cacagagtggaaatcaccgagggcatcctcgctgatgagtgcgccgctctgctgagcgacttcttccggatgcctagacgggtgttcaaggcccaaaaaaaggcccagagcagcatcaactctggaggatctagcggaggatcctct

ggcagcgagacaccaggaacaagcgagtcagcaacaccagagagcagtggcggcagcagcggcggcagcgacaagaagtacagcatcggcctggccatcggcaccaactctgtgggctgggccgtgatcaccgacgagtac

aaggtgcccagcaagaaattcaaggtgctgggcaacaccgaccggcacagcatcaagaagaacctgatcggagccctgctgttcgacagcggcgaaacagccgaggccacccggctgaagagaaccgccagaagaagataca

ccagacggaagaaccggatctgctatctgcaagagatcttcagcaacgagatggccaaggtggacgacagcttcttccacagactggaagagtccttcctggtggaagaggataagaagcacgagcggcacc………….

 

参考文献

Wu, Y., Xiao, Y.-L. & Tang, W. High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase. Nat. Biotechnol. (2025)

 

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