-80℃储存，低温运输。
包装内容：
产品编号 | 产品名称 | 包装 |
N1069 | Tad-CBE3.6 mRNA (1mg/ml) | 100/1000μg |
产品简介：
TadAC2.4经第三轮“负筛”定向进化，loop3（26-30）RDVPV→QNPPV突变。
C编辑效率：≈55%；A背景0.8 % ± 1.0 %。核苷酸特异性≈100倍。
CDS (5376nt):
atgaaacggacagccgacggaagcgagttcgagtcaccaaagaagaagcggaaagtctccgaggtggaattctctcacgagtactggatgaggcatgccctgaccctggccaagcgggcctgggatgagggtaatcctcctgtgg
gcgccgtgctggtgcacaacaaccgggtcatcggcgagggctggaatagagccatcggaagacacgaccccaccgcccacgccgagatcatggccctgcggcagggcggcctggtgatgcagaactacagactgatcgacgcc
acactgtacagcacactggaaccttgtgtgatgtgcgccggcgccatgatccacagcagaatcggcagagttgtgtttggagctagatacctgagaatgggcgctgccggatctctgatgaacgtgctgcactatcctggcattaagca
cagagtggaaatcaccgagggcatcctcgctgatgagtgcgccgctctgctgagcgacttcttccggatgcctagacgggtgttcaaggcccaaaaaaaggcccagagcagcatcaactctggaggatctagcggaggatcctctgg
cagcgagacaccaggaacaagcgagtcagcaacaccagagagcagtggcggcagcagcggcggcagcgacaagaagtacagcatcggcctggccatcggcaccaactctgtgggctgggccgtgatcaccgacgagtacaa
ggtgcccagcaagaaattcaaggtgctgggcaacaccgaccggcacagcatcaagaagaacctgatcggagccctgctgttcgacagcggcgaaacagccgaggccacccggctgaagagaaccgccagaagaagatacacc
agacggaagaaccggatctgctatctgcaagagatcttcagcaacgagatggccaaggtggacgacagcttcttccacagactggaagagtccttcctggtggaagaggataagaagcacgagcggca………….
参考文献
Wu, Y., Xiao, Y.-L. & Tang, W. High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase. Nat. Biotechnol. (2025)
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