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全球最大CRISPR工具平台(蛋白/mRNA)
The World's Largest Precision Gene/Base/Prime Editing Arsenal
-80℃储存,低温运输。
产品编号 | 产品名称 | 包装 |
N1081 | evoCas9 mRNA (1mg/ml) | 100/1000μg |
名称/别名:evoCas9
CRISPR类型:Type II-A(SpCas9衍生)
肽链长度:1,368 aa(与WT SpCas9一致)
活性:dsDNA双链切割,最佳活性需Mg²⁺;在59个靶位点测试中仅检出4个脱靶位点,特异性最高
特性:
高保真突变组合体,脱靶率<0.7%(WT的0.7%)
保持与WT相当的on-target活性
产生WT类似的+1插入频率,用于保证编码区移码
应用:高特异性基因敲除、临床级基因编辑、+1插入介导的移码修复
CDS (4272nt):
atggactataaggaccacgacggagactacaaggatcatgatattgattacaaagacgatgacgataagatggccccaaagaagaagcggaaggtcggtatccacggagtcccagcagccgacaagaagtacagcatcggcctgg
acatcggcaccaactctgtgggctgggccgtgatcaccgacgagtacaaggtgcccagcaagaaattcaaggtgctgggcaacaccgaccggcacagcatcaagaagaacctgatcggagcgctgctgttcgacagcggcgaaa
cagccgaggccacccggcttaagagaaccgccagaagaagatacaccagacggaagaaccggatctgctatctgcaagagatcttcagcaacgagatggccaaggtggacgacagcttcttccacagactggaagagtccttcct
ggtggaagaggataagaagcacgagcggcaccccatcttcggcaacatcgtggacgaggtggcctaccacgagaagtaccccaccatctaccacctgagaaagaaactggtggacagcaccgacaaggccgacctgcggctgat
ctatctggccctggcccacatgatcaagttccggggccacttcctgatcgagggcgacctgaaccccgacaacagcgacgtggacaagctgttcatccagctggtgcagacctacaaccagctgttcgaggaaaaccccatcaacgc
cagcggcgtggacgccaaggccatcctgtctgccagactgagcaagagcagacggctggaaaatctgatcgcccagctgcccggcgagaagaagaatggcctgttcggaaacctgattgccctgagcctgggcctgacccccaa
cttcaagagcaacttcgacctggccgaggatgccaaact………….
Schmid-Burgk, J. L. et al. Highly parallel profiling of Cas9 variant specificity. Mol. Cell 78, 4 (2020).
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