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全球最大CRISPR工具平台(蛋白/mRNA

The World's Largest Precision Gene/Base/Prime Editing Arsenal

HypaCas9 mRNA

HypaCas9 mRNA

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货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1090

HypaCas9 mRNA (1mg/ml)

100/1000μg

 

产品简介:

名称/别名: HypaCas9(高保真Cas9变体)

CRISPR类型: II型(基于SpCas9的工程化变体)

活性: 核酸内切酶活性(诱导双链断裂),显著增强同源定向修复(HDR),抑制非同源末端连接(NHEJ

高保真性:通过特定突变增强构象检查点阈值,减少脱靶效应。

优化HDR/NHEJ比例:在多个内源基因位点显著提升HDR效率,同时抑制NHEJ

大片段插入能力:高效介导长片段DNA(如~4.2 kb)的靶向整合。

 

CDS (4938nt):

atggactataaggaccacgacggagactacaaggatcatgatattgattacaaagacgatgacgataagatggccccaaagaagaagcggaaggtcggtatccacggagtcccagcagccgacaagaagtacagcatcggcctgg

acatcggcaccaactctgtgggctgggccgtgatcaccgacgagtacaaggtgcccagcaagaaattcaaggtgctgggcaacaccgaccggcacagcatcaagaagaacctgatcggagccctgctgttcgacagcggcgaaa

cagccgaggccacccggctgaagagaaccgccagaagaagatacaccagacggaagaaccggatctgctatctgcaagagatcttcagcaacgagatggccaaggtggacgacagcttcttccacagactggaagagtccttcct

ggtggaagaggataagaagcacgagcggcaccccatcttcggcaacatcgtggacgaggtggcctaccacgagaagtaccccaccatctaccacctgagaaagaaactggtggacagcaccgacaaggccgacctgcggctgat

ctatctggccctggcccacatgatcaagttccggggccacttcctgatcgagggcgacctga………….

 

参考文献

Kato-Inui, T. et al. Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair. Nucleic Acids Res. 46, 46774688 (2018).

 

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