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全球最大CRISPR工具平台(蛋白/mRNA

The World's Largest Precision Gene/Base/Prime Editing Arsenal

hfCas12Max mRNA

hfCas12Max mRNA

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货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1136

hfCas12Max mRNA (1mg/ml)

100/1000μg

 

产品简介:

名称/别名:hfCas12Max(高保真Cas12Max

CRISPR类型:Type V-IV-ICas系统)

肽链长度:1033-1093个氨基酸(aa

高效介导哺乳动物细胞基因组编辑(平均编辑效率70%

支持碱基编辑(A-to-G转换效率达80%

依赖TN/TNN PAM识别靶位点

通过三重点突变(N243R/E336R/D892R)显著提升编辑效率与特异性

极低脱靶效应(经PEM-seq验证)

PAM识别范围(兼容TN/TNN等非经典PAM

CDS (3411nt):

atggactataaggaccacgacggagactacaaggatcatgatattgattacaaagacgatgacgataagatggccccaaagaagaagcggaaggtcggtatccacggagtcccagcagccatgagttctgatgtggtgcggccttat

aacacaaagctgctcccagataacagaaagcacaatatgttcctgcagaccttcaagcggctgaacagcatctctctgaaccacttcgacctgctgatctgcctgtacgctgcaatcaccaacaagaaggccgaggaatacaagtctga

aaaggaagcccacgtgaccgccgatagcctgtgtgccatcaattggttcagacccatgagcaagagatacagcaaatacgccaccaccaccttcaacatgttagaactgtttaaggagtacagcggccacgagcctgatgcctattcc

aagaactacctgatgagcaatatcgacagcgacagattcgtgtgggtggattgtaggaagttcgctaaggactttgcctatcagatggaactgggtttccacgagttcaccgtgttggccgaaaccctgctggctaattctatcctggtgct

gaacgagagcaccaaggccaattgggcttggggaaccgtgtctgccctgtacggcggcggagataaggaggacagcacactgaagagcaagattctgctggccttcgtggacgccctgaacaaccacgagctgaaaacaaagag

agaaatcttgaatcaagtgtgtgaatctctgaaataccagagctaccaggacatgtacgtggattttagaagcgtggttgacgaaaacggcaacaagaagtctcctagaggctctatgcctatcgtgaccaagttcgagacagacgacct

gatcagcgacaaccaaagaaaggccatgatcagca………….

 

参考文献

Zhang, H. et al. An engineered xCas12i with high activity, high specificity, and broad PAM range. Protein Cell 14, 538–543 (2023).

 

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