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全球最大CRISPR工具平台(蛋白/mRNA)
The World's Largest Precision Gene/Base/Prime Editing Arsenal
-80℃储存,低温运输。
产品编号 | 产品名称 | 包装 |
N1136 | hfCas12Max mRNA (1mg/ml) | 100/1000μg |
名称/别名:hfCas12Max(高保真Cas12Max)
CRISPR类型:Type V-I(V-I型Cas系统)
肽链长度:约1033-1093个氨基酸(aa)
高效介导哺乳动物细胞基因组编辑(平均编辑效率70%)
支持碱基编辑(A-to-G转换效率达80%)
依赖TN/TNN PAM识别靶位点
通过三重点突变(N243R/E336R/D892R)显著提升编辑效率与特异性
极低脱靶效应(经PEM-seq验证)
宽PAM识别范围(兼容TN/TNN等非经典PAM)
CDS (3411nt):
atggactataaggaccacgacggagactacaaggatcatgatattgattacaaagacgatgacgataagatggccccaaagaagaagcggaaggtcggtatccacggagtcccagcagccatgagttctgatgtggtgcggccttat
aacacaaagctgctcccagataacagaaagcacaatatgttcctgcagaccttcaagcggctgaacagcatctctctgaaccacttcgacctgctgatctgcctgtacgctgcaatcaccaacaagaaggccgaggaatacaagtctga
aaaggaagcccacgtgaccgccgatagcctgtgtgccatcaattggttcagacccatgagcaagagatacagcaaatacgccaccaccaccttcaacatgttagaactgtttaaggagtacagcggccacgagcctgatgcctattcc
aagaactacctgatgagcaatatcgacagcgacagattcgtgtgggtggattgtaggaagttcgctaaggactttgcctatcagatggaactgggtttccacgagttcaccgtgttggccgaaaccctgctggctaattctatcctggtgct
gaacgagagcaccaaggccaattgggcttggggaaccgtgtctgccctgtacggcggcggagataaggaggacagcacactgaagagcaagattctgctggccttcgtggacgccctgaacaaccacgagctgaaaacaaagag
agaaatcttgaatcaagtgtgtgaatctctgaaataccagagctaccaggacatgtacgtggattttagaagcgtggttgacgaaaacggcaacaagaagtctcctagaggctctatgcctatcgtgaccaagttcgagacagacgacct
gatcagcgacaaccaaagaaaggccatgatcagca………….
Zhang, H. et al. An engineered xCas12i with high activity, high specificity, and broad PAM range. Protein Cell 14, 538–543 (2023).
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