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全球最大CRISPR工具平台(蛋白/mRNA

The World's Largest Precision Gene/Base/Prime Editing Arsenal

BhCas12b mRNA

BhCas12b mRNA

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货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1147

BhCas12b mRNA (1mg/ml)

100/1000μg

 

产品简介:

名称/别名:BhCas12bBacillus hisashii Cas12b

CRISPR类型:Type V-B

肽链长度:1108个氨基酸(aa

稳健的哺乳动物基因组编辑(依赖工程化sgRNA

偏好性切割非靶链(野生型),工程化后实现双链断裂

经工程化改造(v4突变体:K846R/S893R/E837G)提升双链切割效率

识别5'-ATTN PAM(兼容TTTN/GTTN

高特异性(脱靶率显著低于SpCas9

 

CDS (3522nt):

atggccccaaagaagaagcggaaggtcggtatccacggagtcccagcagccggatccgccaccagatccttcatcctgaagatcgagcccaacgaggaagtgaagaaaggcctctggaaaacccacgaggtgctgaaccacgg

aatcgcctactacatgaatatcctgaagctgatccggcaagaggccatctacgagcaccacgagcaggaccccaagaatcccaagaaggtgtccaaggccgagatccaggccgagctgtgggatttcgtgctgaagatgcagaagt

gcaacagcttcacacacgaggtggacaaggacgaggtgttcaacatcctgagagagctgtacgaggaactggtgcccagcagcgtggaaaagaagggcgaagccaaccagctgagcaacaagtttctgtaccctctggtggaccc

caacagccagtctggaaagggaacagccagcagcggcagaaagcccagatggtacaacctgaagattgccggcgatccctcctgggaagaagagaagaagaagtgggaagaagataagaaaaaggacccgctggccaagatc

ctgggcaagctggctgagtacggactgatccctctgttcatcccctacaccgacagcaacgagcccatcgtgaaagaaatcaagtggatggaaaagtcccggaaccagagcgtgcggcggctggataaggacatgttcattcaggcc

ctggaacggttcctgagctgggagagctggaacctgaaagtgaaagaggaatacgagaaggtcgagaaagagtacaagaccctggaagagaggatcaaagaggacatccaggctctgaaggctctggaacagtatgagaaaga

gcggcaagaacagctgctgcgggacaccctgaacacca………….

 

参考文献

Strecker, J. et al. Engineering of CRISPR-Cas12b for human genome editing. Nat. Commun. 10, 212 (2019).

 

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