购热线:13202066085(微信同号)

订购/支持:theta_gene@163.com

公司网址:https://www.theta-gene.com

全球最大CRISPR工具平台(蛋白/mRNA

The World's Largest Precision Gene/Base/Prime Editing Arsenal

OsCas12f1 mRNA

OsCas12f1 mRNA

0.00
0.00
货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1152

OsCas12f1 mRNA (1mg/ml)

100/1000μg

 

产品简介:

名称/别名:OsCas12f1Oscillibacter sp. Cas12f1

CRISPR类型:Type V-F

原始编辑效率中等(1-20%),工程化后(enOsCas12f1)显著提升(9.4倍于野生型)

高效诱导大片段缺失(如DMD外显子51缺失)

识别5'-YTTHY=C/T, HGPAM

蛋白尺寸超紧凑(433 aa),可单AAV递送

工程化变体(enOsCas12f1)通过精氨酸突变和sgRNA优化增强活性

 

CDS (1443nt):

atggactataaggaccacgacggagactacaaggatcatgatattgattacaaagacgatgacgataagatgcctaagaagaagagaaaggtgatgggaaagggcgtgctggccaaggtgatgaaatacgagctgagatacctgga

tggttgtggcgacttcagcaatatgcaggagcaggtgtgggccctgcagcggcagacacgggaaatcctgaacagatccatccaaatcgccttccaatgggactgcgccaacagcgagcaccacagaaagaccggcgagtacctg

gacctgaaaacggaaaccggctacaagagactggatggccacatctacaactgcctgaagggccagtacgaggacatggccacatctaacctgaacgccaccatccagaaggcttggaagaagtataactccagcaagaaggaaa

tcctgaggggcagcatgagcatccccagctacaagatgaaccagcctctgacactggacaagaataccgtgaaactgtctgagggcgagcggaacccaatcgtgaccctgacactgtttagcgacaagttcaagcgggcccagggc

gtgtccaacgtgaagtttagcatgcctctgcacgacggcacccagagagccatcttcgccaacctgatgaacggcacctaccagctgggagagtgccagctggtgtacaaacggcctaagtggttcctgttcgtgacatacaagttccc

ccccgtggaacatcctctcgatcctgacaagattctgggcgtcgacatgggcgaggcctgcgcgctttatgcctctacattcggcgagcacggctacctgaagatcgatggaggcgagattacaaagtacgccaagaagatggaagct

agaatccggagcatgcagaagcaggctgctcactgtggcgaaggcagaatcgggcacggcaccaaaacaagagtgtctgtggtgtaccaggccaaggacaaggtggccagattcagagataccatcaac………….

 

参考文献

Kong, X. et al. Engineered CRISPR-OsCas12f1 and RhCas12f1 with activities and expanded target range for genome editing. Nat. Commun. 14, 2836 (2023).

 

可选项: