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全球最大CRISPR工具平台(蛋白/mRNA

The World's Largest Precision Gene/Base/Prime Editing Arsenal

SsCBE mRNA

SsCBE mRNA

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货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1227

SsCBE mRNA   (1mg/ml)

100/1000μg

 

产品简介:

SsCBE的核心蛋白SsdAtox来源于Pseudomonassyringae(丁香假单胞菌)的毒素。SsdAtox属于DYW-like脱氨酶家族,该家族通常针对RNA,但SsdAtox对单链DNA(ssDNA)具有脱氨酶活性。

SsCBE是一种基于PseudomonassyringaeDYW-like脱氨酶SsdAtox的新型碱基编辑器。通过基因工程改造,SsCBE在核基因组和线粒体基因组中均表现出高效的CT编辑能力,同时具有较低的细胞毒性和脱靶效应。其紧凑的结构和多样化的应用方式使其成为基因编辑领域的一个重要工具,为未来的基因治疗提供了新的可能性。

CDS (4209nt):

atgaagaagccttattccatcggcttggacatcgggactaactccgtcggatgggctgtgattaccgacgactacaaggttcccgcaaaaaagatgaaagtgctcggcaatacagatcggtcacatattaagaagaacctgattggcgct

ctgcttttcgatgcaggtaatactgccgaggataggcgcctcaagagaacagcccggcgtagatacactcgcagaaggaaccggattctgtacctgcaagaaatttttgctgaagaaatgaataagatcgatgagtcattcttccaccga

ctggacgatagtttcctggtacctgaagacaaaaggggatccaagtaccccatttttgccacactccaagaagagaaggagtaccacaagcaatttccgaccatctaccaccttaggaagcagctggcagagtccaacgaaaaggcag

acttgcggttagtctacctggctcttgcacacatgataaagtaccggggacatttcttaattgacgaccctaagtttaaagttcagaataacgatattcaaggcctcttcgaaaagtttgttgaggaatatgataacgtacaagaaacctctttgt

ctaaaattaagctcaatgtgactgagatcctcacagcaaagattcccaaaagcgagaaacaagagcaactcctgaagaactaccctagtgagaaaaagaacaccctttttggcaatctgatcgggctcgccctgggcctgacacctaac

ttcaaaacaaatttctccctggagaacgacgccaagctgcaaatctcatccgagagttacgaggaagacttaggatctctcctcgcactgattggagaaaacttcattgaactcttctccgccgtgaaaaatctgagtgacggcatccttct

ggccggaatcgtctctgacgagagtccccacgcgccgctgagcacaaagatggtcatccggttcaaagagcacgaagaagatctcgcggcactcaaacatttcatcaaagccaacttgccagaaaaat………….

参考文献

Kweon, J. et al. High-efficiency base editing for nuclear and mitochondrial DNA with an optimized DYW-like deaminase. Mol. Ther. J. Am. Soc. Gene Ther. S1525-0016(25)00637–9 (2025) doi:10.1016/j.ymthe.2025.08.007.


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