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全球最大CRISPR工具平台(蛋白/mRNA

The World's Largest Precision Gene/Base/Prime Editing Arsenal

TnpBSuper mRNA

TnpBSuper mRNA

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货号:
  

-80℃储存,低温运输。

 

包装内容:

产品编号

产品名称

包装

N1282

TnpBSuper mRNA (1mg/ml)

100/1000μg

 

产品简介:

对野生型TnpB进行全方位优化(蛋白进化+向导RNA优化+密码子优化),引入9个关键点突变,并采用Trim2缩短型向导RNA,超紧凑型(408 aa)

蛋白来源与进化路径

TnpBSuper 的起点是 野生型ISDra2 TnpB

引入了9个氨基酸替换突变,包括 E64K, E66K, E67K, E73K, L155V, L172V, V192L, G299A, A378T

 

CDS序列(1224nt

atgatccggaacaaggccttcgtggtgaggctgtaccccaacgccgcccagacagagctgatcaatagaaccctgggcagcgccaggttcgtgtacaatcacttcctggccaggaggatcgccgcctacaaggagtccggcaagg

gcctgacatacggccagacatccagcgagctgaccctgctgaagAaggccAagAagacatcctggctgagcAaggtggacaagtttgccctgcagaacagcctgaagaatctggagaccgcctacaagaacttcttcagaaca

gtgaagcagagcggcaagaaggtgggctttcccaggttcagaaagaagagaacaggcgagagctacaggacacagtttacaaataacaacatccagatcggcgagggcaggctgaagctgcctaagctgggctgggttaagaca

aagggccagcaggatattcagggcaagatcGtgaatgtgacagtgagaaggattcatgagggccactacgaggccagcgtgGtgtgtgaggtggagatcccctacctgcccgccgctcctaagttcgccgccggagttgatCtgg

gcatcaaggactttgccatcgtgaccgacggcgtgagatttaagcacgagcagaaccctaagtactacaggagcacactgaagaggctgaggaaggcccagcagacactgtccagaagaaagaagggcagcgcccggtacggc

aaggccaagacaaagctggccaggattcataagagaatcgtgaataagaggcaggactttctgcacaagctgaccacaagcctggtgagggagtacgagatcatcggcacagagcacctgaagcctgataacatgaggaagaaca

ggagactggccctgtccatcagcgatgccgCctggggagagtttatcagacagctggagtacaaggccgcctggtacggcagactggtgagcaaggtgagcccttacttccccagctcccagctgtgtc……….

 

参考文献

Gorbenko, F. et al. Directed evolution of compact RNA-guided nucleases for homology–directed repair in mammalian cells. Preprint at https://doi.org/10.1101/2025.10.27.684765 (2025).


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