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公司网址:https://www.theta-gene.com
全球最大CRISPR工具平台(蛋白/mRNA)
The World's Largest Precision Gene/Base/Prime Editing Arsenal
-80℃储存,低温运输。
产品编号 | 产品名称 | 包装 |
N1282 | TnpBSuper mRNA (1mg/ml) | 100/1000μg |
对野生型TnpB进行全方位优化(蛋白进化+向导RNA优化+密码子优化),引入9个关键点突变,并采用Trim2缩短型向导RNA,超紧凑型(约408 aa)
蛋白来源与进化路径
TnpBSuper 的起点是 野生型ISDra2 TnpB。
引入了9个氨基酸替换突变,包括 E64K, E66K, E67K, E73K, L155V, L172V, V192L, G299A, A378T。
CDS序列(1224nt)
atgatccggaacaaggccttcgtggtgaggctgtaccccaacgccgcccagacagagctgatcaatagaaccctgggcagcgccaggttcgtgtacaatcacttcctggccaggaggatcgccgcctacaaggagtccggcaagg
gcctgacatacggccagacatccagcgagctgaccctgctgaagAaggccAagAagacatcctggctgagcAaggtggacaagtttgccctgcagaacagcctgaagaatctggagaccgcctacaagaacttcttcagaaca
gtgaagcagagcggcaagaaggtgggctttcccaggttcagaaagaagagaacaggcgagagctacaggacacagtttacaaataacaacatccagatcggcgagggcaggctgaagctgcctaagctgggctgggttaagaca
aagggccagcaggatattcagggcaagatcGtgaatgtgacagtgagaaggattcatgagggccactacgaggccagcgtgGtgtgtgaggtggagatcccctacctgcccgccgctcctaagttcgccgccggagttgatCtgg
gcatcaaggactttgccatcgtgaccgacggcgtgagatttaagcacgagcagaaccctaagtactacaggagcacactgaagaggctgaggaaggcccagcagacactgtccagaagaaagaagggcagcgcccggtacggc
aaggccaagacaaagctggccaggattcataagagaatcgtgaataagaggcaggactttctgcacaagctgaccacaagcctggtgagggagtacgagatcatcggcacagagcacctgaagcctgataacatgaggaagaaca
ggagactggccctgtccatcagcgatgccgCctggggagagtttatcagacagctggagtacaaggccgcctggtacggcagactggtgagcaaggtgagcccttacttccccagctcccagctgtgtc……….
Gorbenko, F. et al. Directed evolution of compact RNA-guided nucleases for homology–directed repair in mammalian cells. Preprint at https://doi.org/10.1101/2025.10.27.684765 (2025).
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